(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine 4-methylben - Names and Identifiers
Name | (2R,3S)-2-[(1R)-l-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-morpholine, 4-Methylbenzenesulfonate
|
Synonyms | -1-(3,5-Bis(trifluoromethyl) (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine 4-methyl (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]-ethoxy]-3-(4-fluorophenyl)morpholine tosylate (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine 4-methylben (2R,3S)-2-((R)-1-(3,5-Bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine 4-Methylbenzenesulfonate (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate (2R,3S)-2-[(1R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethoxy]-3-(4-Fluorophenyl)Morpholine 4-Methylbenzenesulfonate (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate (2R,3S)-2-[(1R)-l-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-morpholine, 4-Methylbenzenesulfonate Morpholine,2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-,(2R,3S)-, 4-methylbenzenesulfonate (2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine,4-methylbenzenesulfonic acid Morpholine, 2-[(1R)-1-[3,5-bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2R,3S)-, 4-Methylbenzenesulfonate
|
CAS | 200000-59-5
|
InChI | InChI=1S/C20H18F7NO2.C7H8O3S/c1-11(13-8-14(19(22,23)24)10-15(9-13)20(25,26)27)30-18-17(28-6-7-29-18)12-2-4-16(21)5-3-12;1-6-2-4-7(5-3-6)11(8,9)10/h2-5,8-11,17-18,28H,6-7H2,1H3;2-5H,1H3,(H,8,9,10)/t11-,17+,18-;/m1./s1 |
(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine 4-methylben - Physico-chemical Properties
Molecular Formula | C27H26F7NO5S
|
Molar Mass | 609.56 |
Appearance | Solid |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Sensitive | IRRITANT |
MDL | MFCD13183777 |
(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine 4-methylben - Introduction
(2R,3S)-2-[(1R)-l-[3,5-bis (trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-morpholine, 4-Methylbenzenesulfonate is an organic compound. Its Properties, Uses, preparation methods and safety information are as follows:
Nature:
-chemical formula: C23H23F5NO3S
-Appearance: White solid
-Melting point: About 150-155 ° C
-Solubility: Slightly soluble in water, soluble in organic solvents such as acetonitrile, dimethyl sulfoxide and chloroform
Use:
(2R,3S)-2-[(1R)-l-[3,5-bis (trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-morpholine, 4-Methylbenzenesulfonate is widely used in the field of medicine, mainly as a synthetic intermediate of chiral drugs. It can be used to synthesize biologically active compounds, such as anti-inflammatory drugs and anti-cancer drugs.
Method:
(2R,3S)-2-[(1R)-l-[3,5-bis (trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-morpholine, the preparation of 4-Methylbenzenesulfonate typically involves a multi-step reaction. A common synthesis method includes the following steps:
1. Benzene sulfonic acid with (2R,3S)-2-[(1R)-1-[3,5-bis (trifluoromethyl)) phenyl] ethoxy]-3-(4-fluorophenyl) morpholine reacts to generate (2R,3S)-2-[(1R)-1-[3, 5-Bis (trifluoromethyl) phenyl] ethoxy]-3-(4-fluorophenyl) morpholine benzenesulfonate.
2. The resulting compound is purified and crystallized to obtain the final product.
Safety Information:
About (2R,3S)-2-[(1R)-l-[3,5-bis (trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-morpholine, specific safety information on 4-Methylbenzenesulfonate requires reference to the safety data sheet of the relevant chemical and the safety instructions provided by the chemical supplier. Appropriate laboratory practices and personal protective measures should be taken to comply with relevant safety regulations when handling and using chemicals.
Last Update:2024-04-09 21:54:55